Helicobacter pylori (H. pylori)

noreply@blogger.com (Jon Brassey) — Fri, 11 May 2007 07:59:00 +0000

This review is a pragmatic attempt to highlight recent research and some background reading on AAA. It should not be considered exhaustive, simply a way of reviewing some of the major developments and current thinking in the area.

Click here to see all the TRIP Evidence Reviews.

Related Review: Dyspepsia

Evidence-Based Reports

Eradication of chronic H pylori reduces risk of gastric cancer. POEMs, 2005
1 day quadruple therapy was not inferior to 7 day triple therapy for eradication of Helicobacter pylori infection in dyspepsia. Evidence-Based Medicine (Requires free registration), 2005
Helicobacter pylori eradication may cause minor worsening of gastro-oesophageal disease. POEMs, 2004
One day treatment is as effective as seven to eradicate H pylori. POEMs, 2005
Peptic ulcer is rare without H pylori or NSAID. Bandolier Extra, 2004
The management of dyspepsia in primary care. MeReC, 2006
The initial management of dyspepsia in primary care. MeReC, 2006

Clinical Guidelines

Treatment of Helicobacter Pylori Infection in Adults. Towards Optimized Practice, 2007
Management of helicobacter pylori infection. Singapore Ministry of Health, 2004
American Gastroenterological Association medical position statement: evaluation of dyspepsia, 2005
Initial management of dyspepsia and GERD. Institute for Clinical Systems Improvement, 2006
Dyspepsia - proven DU, GU, or NSAID-associated ulcer. PRODIGY, 2005
Dyspepsia - proven non-ulcer dyspepsia. PRODIGY, 2005
Dyspepsia - symptoms (uninvestigated by endoscopy). PRODIGY, 2005

Systematic Reviews

Impact of helicobacter pylori eradication on dyspepsia, health resource use, and quality of life in the Bristol helicobacter project: randomised controlled trial. NHS EED, 2006
Cost-effectiveness of Helicobacter pylori "test and treat" for patients with typical reflux symptoms in a population with a high prevalence of H. pylori infection: a Markov model analysis. NHS EED, 2006
'Best practice' for Helicobacter pylori eradication in the primary care setting. NHS EED, 2006
Eradication of Helicobacter pylori for non-ulcer dyspepsia. Cochrane Database of Systematic Reviews, 2006
Eradication therapy for peptic ulcer disease in Helicobacter pylori positive patients. Cochrane Database of Systematic Reviews, 2006
Meta-analysis: role of Helicobacter pylori eradication in the prevention of peptic ulcer in NSAID users. DARE, 2005
Helicobacter pylori-associated ulcer bleeding: should we test for eradication after treatment. NHS EED, 2005
Economic evaluation of empirical antisecretory therapy versus Helicobacter pylori test for management of dyspepsia: a randomized trial in primary care. NHS EED, 2006

Recent articles in core journals

Meta-analysis: the effect of supplementation with probiotics on eradication rates and adverse events during Helicobacter pylori eradication therapy. Aliment Pharmacol Ther, 2007
Helicobacter pylori eradication in long-term proton pump inhibitor users in primary care: a randomized-controlled trial. Aliment Pharmacol Ther, 2007
Meta-analysis: Helicobacter pylori eradication treatment efficacy in children. Aliment Pharmacol Ther, 2007
Clarithromycin-resistant genotypes and eradication of Helicobacter pylori. Annals of Internal Medicine, 2006
Thyroxine in goiter, Helicobacter pylori infection, and chronic gastritis. NEJM, 2006
13C urea breath test for (Helicobacter pylori): determination of the optimal cut-off point in a Canadian community population. Can J Gastroenterol, 2006
Levofloxacin-Based Triple Therapy in First-Line Treatment for Helicobacter pylori Eradication. Am J Gastroenterol, 2006
13C urea breath test for (Helicobacter pylori): evaluation of 10-minute breath collection. Can J Gastroenterol, 2006
Accuracy of monoclonal stool antigen test for the diagnosis of H. pylori infection: a systematic review and meta-analysis. Am J Gastroenterol, 2006

eTextbooks

Clinical Queries

What is the best initial eradication regime for helicobacter pylori, in the patient allergic to amoxicillin? NLH Q&A Service, 2006
Does the presence of helicobacter pylori in the stomach increase the risk of developing stomach cancer? ATTRACT, 2004
How likely is H Pylori to return after eradication? If it does return is further triple therapy required even if the patient is asymptomatic? NLH Q&A Service, 2007
Can you give me the basic details of a stool antigen test for H. pylori. info re sensitivity, specificity, cost etc would be useful especially in contrast with the urea breath test? NLH Q&A Service, 2007
What is the natural history of H. pylori serology - when does it become negative, if ever, after eradication therapy? NLH Q&A Service, 2006
If you have to use a tetracycline for H. pylori eradication, what is the dosage? NLH Q&A Service, 2006
Is it worthwhile to do a breath test in an asymptomatic adult after eradication treatment? NLH Q&A Service, 2006

Other Links

Health Protection Agency Fact Sheet

Patient Information

TRIP Evidence Reviews: Helicobacter pylori

Helicobacter pylori (H. pylori)